Journal
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
Volume 7, Issue -, Pages S54-S59Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1995-7645(14)60203-0
Keywords
Prodrugs; Natural products; Pharmacology
Funding
- authorities of Ratnam Institute of Pharmacy
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A natural prodrug is a chemical compound or substance obtained from plants, microorganism, animal and marine sources. Natural products are small molecule source for Food and Drug Administration approved drugs and major sources for drug discovery. Most of the drugs for different ailment diseases undergo first pass metabolism, resulting in drug inactivation and the generation of toxic metabolites in body. Enormous numbers of prodrugs naturally present in plants, microorganism, animal and marine sources and those prodrugs undergoes chemical reaction to form non-toxic compounds. This review summarizes the list of prodrugs naturally present in the natural product.
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