Journal
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
Volume 6, Issue 8, Pages 631-634Publisher
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
DOI: 10.1016/S1995-7645(13)60108-X
Keywords
Chikungunya virus; Cytokine; Interleukin-6; Granulocyte-macrophage colony - stimulating factor; Monocyte chemotactic protein 1
Funding
- Higher Education Research Promotion and National Research University Project of Thailand
- Office of the Higher Education Commission [HR1155A]
- Thailand Research Fund [DPG5480002]
- Commission on Higher Education
- Ministry of Education
- Center of Excellence in Clinical Virology, Chulalongkorn University, Centenary Academic Development Project
Ask authors/readers for more resources
Objective: To investigate cytokine profile in patients with chikungunya virus (CHIKV) infection. Methods: Twenty eight pairs of serum samples collected from CHIKV infected patients during the outbreak of chikungunya fever in South Thailand in 2008 were obtained. A multiple cytokine assay for detection of 17 cytokines was performed. Results: In the acute stage of CHIKV infection, the patients had significantly higher levels of interleukin-6, granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, monocyte chemotactic protein 1 and tumor necrosis factor alpha than the control (P<0.001, P=0.023, P=0.015, P<0.001 and P=0.024, respectively). When the disease developed to the recovery stage, the patients had significantly lower levels of interleukin-6, granulocyte-macrophage colony-stimulating factor, monocyte chemotactic protein 1 and macrophage inflammatory protein beta than in the acute stage (P<0.001). Conclusions: This study provides additional information that these cytokines could play roles in pathogenesis of CHIKV infection and could be used as disease biomarkers or drug targets.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available