Journal
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
Volume 6, Issue 4, Pages 253-259Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.1016/S1995-7645(13)60053-X
Keywords
Martynia annua; Wound healing; Flavonoids; Antioxidant; Povidone iodine ointment; Streptozotocin
Funding
- Indian Council of Medical Researcd [45/12/2007/BMS/TRM, 2007-00690]
- Indian Council of Medical Research, New Delhi [45/12/2007/BMS/TRM, 2007-00690]
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Objective: To evaluate wound healing potential of flavonoid fractions of Martynia annua (M. annua) Linn. leaves in diabetic rats on the basis of folkloric information and preliminary study. Methods: The flavonoid compound luteolin and apigenin were isolated from dried leaves of plant by column chromatography. The two concentrations (0.2% and 0.5% w/w) of luteolin and flavonoid fraction were selected for topically applied as ointment on diabetic wound. The Povidone Iodine Ointment USP was used as a reference. On 18th days, protein content, hydroxyproline and antioxidants (SOD, CAT and GSH) level in granuloma tissues were determined. Results: The results showed that, percent wound contraction were observed significantly (P<0.01) greater in MAF fraction and 0.5% w/w of luteolin treatment groups. Presence of matured collagen fibres and fibroblasts with better angiogenesis were observed in histopathological studies. Conclusions: In conclusion, our findings suggest that flavonoid fraction (MAF) and luteolin (0.5% w/w) may have potential benefit in enhancing wound healing in diabetic condition, possibly due to free radical scavenging activity of plant.
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