Anti-inflammatory activity of Premna corymbosa (Burm.f.) Rottl. & Willd. leaves extracts in Wistar albino rats

Objective: To evaluate the acute toxicity and to investigate the effect of Premna corymhosa ethanolic extract (PCEE) at doses of 200 and 400 mg/kg body weight in acute and chronic models of inflammation in experimental animals. Methods: In the acute toxicity study, a single dose of PCEE of 2 000 mg/kg body weight, p.o. was administered and observed for 48 h. In acute models as egg albumin induced paw edema and chronic model as cotton pellet methods was followed. Results: In acute models, egg albumin induced paw edema PCEE significantly (P < 0.01) inhibited the edema formation. In chronic model, cotton pellet induced granuloma formation in rats PCEE significantly (P < 0.01) reduced the granuloma formation with percentage inhibition of 35.17% and 50.38 % respectively. Conclusions: The present study establishes the antiinflammatory activity of Premna corymbosa leaves.