Journal
ARTHRITIS RESEARCH & THERAPY
Volume 13, Issue 3, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/ar3313
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Funding
- Norwegian Research Council
- Helse Bergen, Regional Health Authority for Western Norway
- Broegelmann Foundation
- National Institutes of Health, USA [DE014344, AI0819529, DE018958]
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R00DE018958] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [R01DE014344] Funding Source: NIH RePORTER
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Sjogren's syndrome (SS), a systemic autoimmune disease, is characterized by inflammation of exocrine tissues accompanied by a significant loss of their secretory function. Clinical symptoms develop late and there are no diagnostic tests enabling early diagnosis of SS. Thus, particularly to study these covert stages, researchers turn to studying animal models where mice provide great freedom for genetic manipulation and testing the effect of experimental intervention. The present review summarizes current literature pertaining to both spontaneous and extrinsic-factor induced SS-like diseases in mouse models, discussing advantages and disadvantages related to the use of murine models in SS research.
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