Journal
ARTHRITIS RESEARCH & THERAPY
Volume 13, Issue 3, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/ar3323
Keywords
-
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT)
- ERATO, Japan Science and Technology Agency (Saitama, Japan)
Ask authors/readers for more resources
Studies on the immune regulation of osteoclasts in rheumatoid arthritis have promoted the new research field of 'osteoimmunology', which investigates the interplay between the skeletal and immune systems at the molecular level. Accumulating evidence lends support to the theory that bone destruction associated with rheumatoid arthritis is caused by the enhanced activity of osteoclasts, resulting from the activation of a unique helper T cell subset, 'Th17 cells'. Understanding the interaction between osteoclasts and the adaptive immune system in rheumatoid arthritis and the molecular mechanisms of Th17 development will lead to the development of potentially effective therapeutic strategies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available