Journal
ARTHRITIS RESEARCH & THERAPY
Volume 13, Issue 1, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/ar3236
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Funding
- Dutch Organization of Scientific Research (NWO) [917.66.341]
- Higher Education Funding Council of England
- Medical Research Council [G0801025] Funding Source: researchfish
- MRC [G0801025] Funding Source: UKRI
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Anti-neutrophil cytoplasm autoantibody (ANCA)-associated diseases are autoimmune conditions characterized by necrotizing inflammation of small blood vessels. The immunogenesis and etiology of these conditions are unknown, but our knowledge of the immunopathogenesis has increased considerably in recent years. In this review, we discuss the animal models currently used to investigate the mechanisms of vascular injury and to test novel therapies. We outline their advantages and limitations and propose potential directions for future research.
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