Journal
ARTHRITIS RESEARCH & THERAPY
Volume 11, Issue 1, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/ar2574
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Funding
- Arthritis Research Campaign, UK
- Biotechnology and Biological Sciences Research Council, UK
- Biotechnology and Biological Sciences Research Council [BBS/B/0126X] Funding Source: researchfish
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In a chronically hypoxic tissue such as cartilage, adaptations to hypoxia do not merely include cell survival responses, but also promotion of its specific function. This review will focus on describing such hypoxia-mediated chondrocyte function, in particular in the permanent articular cartilage. The molecular details of how chondrocytes sense and respond to hypoxia and how this promotes matrix synthesis have recently been examined, and specific manipulation of hypoxia-induced pathways is now considered to have potential therapeutic application to maintenance and repair of articular cartilage.
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