Journal
ARTHRITIS RESEARCH & THERAPY
Volume 11, Issue 2, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/ar2631
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Funding
- Arthritis Research Campaign (ARC)
- Marques de Valdecilla Foundation (Spain)
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The increased burden of cardiovascular disease in patients with rheumatoid arthritis and systemic lupus erythematosus has recently become the focus of intense investigation. Pro-atherogenic risk factors and dysregulated inflammation are the main culprits, leading to enhanced atherosclerosis in subgroups of patients with inflammatory diseases. Common molecular pathways shared by atherosclerosis and inflammatory disease may be involved. In this review we map the key determinants of the increased incidence of cardiovascular disease in patients with inflammatory diseases at each step of the atherogenesis.
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