Journal
ARTHRITIS RESEARCH & THERAPY
Volume 10, Issue 4, Pages -Publisher
BMC
DOI: 10.1186/ar2471
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Funding
- Lupus Research Institute
- American College of Rheumatology/Lupus Research Institute Lupus Fellowship
- Kirkland Award
- National Institute of Arthritis, Skin and Musculoskeletal Diseases [1K23AR053864-01A1]
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [K23AR053864] Funding Source: NIH RePORTER
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In this review, the authors discuss the formation and structure of high-density lipoproteins (HDLs) and how those particles are altered in inflammatory or stress states to lose their capacity for reverse cholesterol transport and for antioxidant activity. In addition, abnormal HDLs can become proinflammatory (piHDLs) and actually contribute to oxidative damage. The assay by which piHDLs are identified involves studying the ability of test HDLs to prevent oxidation of low-density lipoproteins. Finally, the authors discuss the potential role of piHDLs (found in some 45% of patients with systemic lupus erythematosus and 20% of patients with rheumatoid arthritis) in the accelerated atherosclerosis associated with some chronic rheumatic diseases.
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