Journal
ARTHRITIS CARE & RESEARCH
Volume 64, Issue 10, Pages 1602-1610Publisher
WILEY
DOI: 10.1002/acr.21728
Keywords
-
Categories
Funding
- Natural Science Foundation of China [81101195]
Ask authors/readers for more resources
Objective To investigate the clinical features of dermatomyositis (DM) and clinically amyopathic DM (CADM) patients with the presence of antimelanoma differentiationassociated gene 5 (antiMDA-5) antibodies. Methods We screened the serum antiMDA-5 antibody levels of 140 patients with various connective tissue diseases (CTDs), including 32 with DM and 32 with CADM, or idiopathic pulmonary fibrosis (IPF). The clinical courses of DM/CADM patients with a positive expression of antiMDA-5 antibodies were delineated. Results AntiMDA-5 antibodies were detected at a significantly higher frequency in CADM patients than in DM patients (12 of 32 versus 3 of 32; P = 0.016), but were not detected in patients with other CTDs or IPF and healthy controls. Patients with a positive expression of antiMDA-5 antibodies developed significantly more skin ulcerations (12 of 15 versus 4 of 49; P < 0.001) and interstitial lung disease (ILD; 15 of 15 versus 31 of 49 [P = 0.003]) than those without antiMDA-5 antibodies. High-resolution computed tomography scores of the MDA-5positive subset were increased compared with the MDA-5negative group (mean +/- SD 117.7 +/- 76.3 versus 54.4 +/- 50.7; P = 0.004), and the scores correlated well with antiMDA-5 antibody levels (r2 = 0.582, P = 0.029). The respiratory symptoms as well as skin ulcerations were dramatically improved in patients with antiMDA-5 antibody levels <500 units/ml after treatment, whereas patients with antiMDA-5 antibody levels >500 units/ml were resistant to the treatment and died of respiratory failure in a short period of time. Conclusion AntiMDA-5 antibody levels closely correlate with the severity of skin ulcerations, ILD, and the prognosis of the disease. Dynamic observation of serum antiMDA-5 antibody levels would be helpful in predicting the course of ILD and facilitating better therapeutic targeting.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available