Journal
ARTHRITIS CARE & RESEARCH
Volume 62, Issue 6, Pages 881-887Publisher
WILEY-LISS
DOI: 10.1002/acr.20122
Keywords
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Categories
Funding
- Canadian Institutes of Health Research [MOP-49529]
- Lupus Foundation of Ontario
- Ontario Lupus Association, Lupus UK
- Lupus Foundation of America
- Lupus Alliance of Western New York
- Conn Smythe Foundation
- Lupus Flare Foundation
- Tolfo family of Toronto, Ontario, Canada
- Brain Korea 21 Program
- Arthritis Research Campaign
- Wellcome Trust
- Birmingham, UK
- Singer Family Fund for Lupus Research
- Fonds de la Recherche en Sante du Quebec National Scholar
- Fonds de la Recherche en Sante du Quebec Jeune Chercheure
- McGill University Health Centre Research Institute
- Canadian Institutes of Health Research
- Canadian Arthritis Network Scholar Award
- Arthritis Centre of Excellence, University of Toronto
- University of Alabama at Birmingham (NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases) [P60-AR-48095]
- Swedish Medical Research Council [13489]
- NIH [UL-1RR-025741, K24-AR-02318, P60-AR-48098]
- Hopkins Lupus Cohort [AR-43727]
- Johns Hopkins University General Clinical Research Center [M01-RR-00052]
- FOGARTY INTERNATIONAL CENTER [F06TW002318] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000048, UL1RR025741, M01RR000052] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [P60AR048098, P60AR048095, K24AR002138] Funding Source: NIH RePORTER
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Objective. To describe vascular events during an 8-year followup in a multicenter systemic lupus erythematosus (SLE) inception cohort and their attribution to atherosclerosis. Methods. Clinical data, including comorbidities, were recorded yearly. Vascular events were recorded and attributed to atherosclerosis or not. All of the events met standard clinical criteria. Factors associated with atherosclerotic vascular events were analyzed using descriptive statistics, t-tests, and chi-square tests. Stepwise multivariate logistic regression was used to assess the association of factors with vascular events attributed to atherosclerosis. Results. Since 2000, 1,249 patients have been entered into the cohort. There have been 97 vascular events in 72 patients, including: myocardial infarction (n = 13), angina (n = 15), congestive heart failure (n = 24), peripheral vascular disease (n = 8), transient ischemic attack (n = 13), stroke (n = 23), and pacemaker insertion (n = 1). Fifty of the events were attributed to active lupus, 31 events in 2
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