Journal
BIOFABRICATION
Volume 1, Issue 3, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1758-5082/1/3/035005
Keywords
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT)
- Japan Society for the Promotion of Science (JSPS) [19100008]
- FCT (Fundacao para a Ciencia e Tecnologia) [PTDC/EQU-FTT/71800/2006]
- Global COE Program 'Global Nano-Biomedical Engineering Education and Research Network'
- Fundação para a Ciência e a Tecnologia [PTDC/EQU-FTT/71800/2006] Funding Source: FCT
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The current microdevices used for biomedical research are often manufactured using microelectromechanical systems (MEMS) technology. Although it is possible to fabricate precise and reproducible rectangular microchannels using soft lithography techniques, this kind of geometry may not reflect the actual physiology of the microcirculation. Here, we present a simple method to fabricate circular polydimethysiloxane (PDMS) microchannels aiming to mimic an in vivo microvascular environment and suitable for state-of-the-art microscale flow visualization techniques, such as confocal mu PIV/PTV. By using a confocal mu PTV system individual red blood cells (RBCs) were successfully tracked trough a 75 mu m circular PDMS microchannel. The results show that RBC lateral dispersion increases with the volume fraction of RBCs in the solution, i.e. with the hematocrit.
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