Journal
VIRUSES-BASEL
Volume 10, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/v10090484
Keywords
virus susceptibility genes; antiviral defense; virus movement; gene silencing; virus resistance; virus accumulation; host factors
Categories
Funding
- NIH [R01GM120108]
- Nebraska Agricultural Experiment Station
- USDA National Institute of Food and Agriculture [1007272]
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Plant viruses use cellular factors and resources to replicate and move. Plants respond to viral infection by several mechanisms, including innate immunity, autophagy, and gene silencing, that viruses must evade or suppress. Thus, the establishment of infection is genetically determined by the availability of host factors necessary for virus replication and movement and by the balance between plant defense and viral suppression of defense responses. Host factors may have antiviral or proviral activities. Proviral factors condition susceptibility to viruses by participating in processes essential to the virus. Here, we review current advances in the identification and characterization of host factors that condition susceptibility to plant viruses. Host factors with proviral activity have been identified for all parts of the virus infection cycle: viral RNA translation, viral replication complex formation, accumulation or activity of virus replication proteins, virus movement, and virion assembly. These factors could be targets of gene editing to engineer resistance to plant viruses.
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