Journal
VIRUSES-BASEL
Volume 5, Issue 5, Pages 1272-1291Publisher
MDPI
DOI: 10.3390/v5051272
Keywords
herpes simplex virus; chromatin; HCF-1; Setd1A; latency; histone demethylase
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Funding
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, USA
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Successful infection of herpes simplex virus is dependent upon chromatin modulation by the cellular coactivator host cell factor-1 (HCF-1). This review focuses on the multiple chromatin modulation components associated with HCF-1 and the chromatin-related dynamics mediated by this coactivator that lead to the initiation of herpes simplex virus (HSV) immediate early gene expression.
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