Journal
VIRUSES-BASEL
Volume 5, Issue 1, Pages 150-161Publisher
MDPI
DOI: 10.3390/v5010150
Keywords
Escherichia coli; biofilm; lysogenic conversion; resistance development; Shiga toxin; phage
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Funding
- Flemish Agency for Innovation by Science and Technology (IWT-Vlaanderen)
- KU Leuven Research Fund [CREA/09/017]
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In this study, three-day old mature biofilms of Escherichia coli were exposed once to either a temperate Shiga-toxin encoding phage (H-19B) or an obligatory lytic phage (T7), after which further dynamics in the biofilm were monitored. As such, it was found that a single dose of H-19B could rapidly lead to a near complete lysogenization of the biofilm, with a subsequent continuous release of infectious H-19B particles. On the other hand, a single dose of T7 rapidly led to resistance development in the biofilm population. Together, our data indicates a profound impact of phages on the dynamics within structured bacterial populations.
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