Journal
VIRUSES-BASEL
Volume 4, Issue 8, Pages 1182-1201Publisher
MDPI
DOI: 10.3390/v4081182
Keywords
herpesvirus; immune suppression; IL-10; CD200; PD-1; BTLA; cytomegalovirus
Categories
Funding
- Wellcome Trust Research Career Development Fellowship
- MRC [G0901119]
- Cardiff University I3-Interdisciplinary Research Group/MRC studentship
- Cardiff University President's Scholarship studentship
- Medical Research Council [G0901119] Funding Source: researchfish
- MRC [G0901119] Funding Source: UKRI
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Herpesviruses employ a plethora of mechanisms to circumvent clearance by host immune responses. A key feature of mammalian immune systems is the employment of regulatory pathways that limit immune responsiveness. The primary functions of these mechanisms are to control autoimmunity and limit exuberant responses to harmless antigen in mucosal surfaces. However, such pathways can be exploited by viral pathogens to enable acute infection, persistence and dissemination. Herein, we outline the current understanding of inhibitory pathways in modulating antiviral immunity during herpesvirus infections in vivo and discuss strategies employed by herpesviruses to exploit these pathways to limit host antiviral immunity.
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