Journal
VIRUSES-BASEL
Volume 3, Issue 11, Pages 2238-2254Publisher
MDPI
DOI: 10.3390/v3112238
Keywords
hepatitis C virus; virus assembly; cellular imaging
Categories
Funding
- French Agence Nationale de Recherche sur le Sida et les hepatites virales (ANRS)
- European Social Fund [POSDRU/89/1.5/S/60746]
- CNCSIS [RP 9/12.08.2010]
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Hepatitis C Virus (HCV) assembly process is the least understood step in the virus life cycle. The functional data revealed by forward and reverse genetics indicated that both structural and non-structural proteins are involved in the assembly process. Using confocal and electron microscopy different groups determined the subcellular localization of different viral proteins and they identified the lipid droplets (LDs) as the potential viral assembly site. Here, we aim to review the mechanisms that govern the viral proteins recruitment to LDs and discuss the current model of HCV assembly process. Based on previous examples, this review will also discuss advanced imaging techniques as potential means to extend our present knowledge of HCV assembly process.
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