Journal
VIRUSES-BASEL
Volume 3, Issue 9, Pages 1757-1776Publisher
MDPI
DOI: 10.3390/v3091757
Keywords
HIV-1; actin; microtubules; virological synapse; dendritic cells; cell-to-cell transfer
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Funding
- Swiss National Science Foundation
- Human Science Frontier Program
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Human immunodeficiency virus 1 (HIV-1) infects T cells, macrophages and dendritic cells and can manipulate their cytoskeleton structures at multiple steps during its replication cycle. Based on pharmacological and genetic targeting of cytoskeleton modulators, new imaging approaches and primary cell culture models, important roles for actin and microtubules during entry and cell-to-cell transfer have been established. Virological synapses and actin-containing membrane extensions can mediate HIV-1 transfer from dendritic cells or macrophage cells to T cells and between T cells. We will review the role of the cytoskeleton in HIV-1 entry, cellular trafficking and cell-to-cell transfer between primary cells.
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