Journal
VIRUSES-BASEL
Volume 3, Issue 6, Pages 906-919Publisher
MDPI
DOI: 10.3390/v3060906
Keywords
RIG-I; inflammation; adjuvant
Categories
Funding
- NIH [R01AI074973, R01DA024563, U19AI083019, R01AI060389 U19AI088778, AI2008038, P30DA015625, U54AI081680, HHSN272200900035C]
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The RNA helicase family of RIG-I-like receptors (RLRs) is a key component of host defense mechanisms responsible for detecting viruses and triggering innate immune signaling cascades to control viral replication and dissemination. As cytoplasm-based sensors, RLRs recognize foreign RNA in the cell and activate a cascade of antiviral responses including the induction of type I interferons, inflammasome activation, and expression of proinflammatory cytokines and chemokines. This review provides a brief overview of RLR function, ligand interactions, and downstream signaling events with an expanded discussion on the therapeutic potential of targeting RLRs for immune stimulation and treatment of virus infection.
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