Journal
VIRUSES-BASEL
Volume 3, Issue 9, Pages 1681-1698Publisher
MDPI AG
DOI: 10.3390/v3091681
Keywords
feline leukemia virus; lymphoma; pathogenesis; oncogenesis; long terminal repeat; surface glycoprotein
Categories
Funding
- NIH, National Cancer Institute [CA83823]
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Detailed analysis has been performed over many years of a geographic and temporal cohort of cats naturally infected with feline leukemia virus (FeLV). Molecular analysis of FeLV present in the diseased tissues and application of those viruses to experimental systems has revealed unique isolates with distinctive disease potential, previously uncharacterized virus-receptor interactions, information about the role of recombinant viruses in disease induction, and novel viral and cellular oncogenes implicated in pathogenesis, among other findings. The studies have contributed to an understanding of the selective forces that lead to predominance of distinctive FeLV isolates and disease outcomes in a natural population.
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