Journal
VIRUSES-BASEL
Volume 2, Issue 1, Pages 1-26Publisher
MDPI
DOI: 10.3390/v2010001
Keywords
genomics; bioinformatics; molecular evolution; pathoepidemiology; field strain; adenovirus vaccine; human gene therapy vector; vaccine delivery vector
Categories
Funding
- graduate student stipend
- U.S. Army Medical Research and Material Command (USAMRMC) [DAMD17-03-2-0089]
- Defense Threat Reduction Agency (DTRA)
- George Mason University
- HQ USAF Surgeon General Office, Directorate of Modernization (SGR)
Ask authors/readers for more resources
Technological advances and increasingly cost-effect methodologies in DNA sequencing and computational analysis are providing genome and proteome data for human adenovirus research. Applying these tools, data and derived knowledge to the development of vaccines against these pathogens will provide effective prophylactics. The same data and approaches can be applied to vector development for gene delivery in gene therapy and vaccine delivery protocols. Examination of several field strain genomes and their analyses provide examples of data that are available using these approaches. An example of the development of HAdV-B3 both as a vaccine and also as a vector is presented.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
