Journal
VIRUSES-BASEL
Volume 2, Issue 12, Pages 2649-2662Publisher
MDPI AG
DOI: 10.3390/v2122649
Keywords
dengue; dengue hemorrhagic fever; prM; ADE; neutralization; cleavage
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Antibody-dependent enhancement (ADE) has been proposed as a mechanism to explain dengue hemorrhagic fever (DHF) in the course of a secondary dengue infection. Very recently, Dejnirattisai et al., 2010 [1], published an important article supporting the involvement of anti-prM antibodies in the ADE phenomenon. The complexity of ADE in the context of a secondary dengue infection is discussed here.
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