Journal
VIRUSES-BASEL
Volume 2, Issue 2, Pages 468-502Publisher
MDPI
DOI: 10.3390/v2020468
Keywords
adenovirus; gene therapy; vaccine; toxicity; PEGylation; targeting; pharmacokinetics; immune response; tolerance; non-viral vectors
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Funding
- American Foundation for Pharmaceutical Education
- Burroughs Wellcome Fund
- University of Texas at Austin
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Covalent modification with polyethylene glycol (PEG), a non-toxic polymer used in food, cosmetic and pharmaceutical preparations for over 60 years, can profoundly influence the pharmacokinetic, pharmacologic and toxciologic profile of protein and peptide-based therapeutics. This review summarizes the history of PEGylation and PEG chemistry and highlights the value of this technology in the context of the design and development of recombinant viruses for gene transfer, vaccination and diagnostic purposes. Specific emphasis is placed on the application of this technology to the adenovirus, the most potent viral vector with the most highly characterized toxicity profile to date, in several animal models.
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