Journal
VIRUSES-BASEL
Volume 2, Issue 5, Pages 1195-1217Publisher
MDPI
DOI: 10.3390/v2051195
Keywords
hepatitis C virus; HCV; lipid metabolism; lipid droplets; fatty acid biosynthesis; cholesterol biosynthesis; VLDL assembly; RNA replication; virus assembly
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Funding
- UK Medical Research Council
- Marie Curie Intra-European Fellowship [025198]
- Australian NHMRC [358772]
- European Union [HEALTH-F4-2008-202272]
- Medical Research Council [MC_U130184143] Funding Source: researchfish
- MRC [MC_U130184143] Funding Source: UKRI
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Chronic infection by hepatitis C virus (HCV) can lead to severe liver disease and is a global healthcare problem. The liver is highly metabolically active and one of its key functions is to control the balance of lipid throughout the body. A number of pathologies have been linked to the impact of HCV infection on liver metabolism. However, there is also growing evidence that hepatic metabolic processes contribute to the HCV life cycle. This review summarizes the relationship between lipid metabolism and key stages in the production of infectious HCV.
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