Journal
VIRUSES-BASEL
Volume 1, Issue 3, Pages 713-736Publisher
MDPI
DOI: 10.3390/v1030713
Keywords
HIV; retroviruses; DNA; integrase; crosslinking; footprinting
Categories
Funding
- NIAID/NIH [AI062520, AI077341]
Ask authors/readers for more resources
Integration of a reverse transcribed DNA copy of the HIV viral genome into the host chromosome is essential for virus replication. This process is catalyzed by the virally encoded protein integrase. The catalytic activities, which involve DNA cutting and joining steps, have been recapitulated in vitro using recombinant integrase and synthetic DNA substrates. Biochemical and biophysical studies of these model reactions have been pivotal in advancing our understanding of mechanistic details for how IN interacts with viral and target DNAs, and are the focus of the present review.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available