Journal
VIRUSES-BASEL
Volume 1, Issue 3, Pages 760-779Publisher
MDPI
DOI: 10.3390/v1030760
Keywords
cytomegalovirus; CMV; innate immunity; intrinsic defense; interferon response; nuclear domain 10; apoptosis; immediate-early genes; IE1; IE2
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Funding
- European Union TargetHerpes [LSHG-CT-2006-037517]
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The major immediate-early (IE) gene of human cytomegalovirus (CMV) is believed to have a decisive role in acute infection and its activity is an important indicator of viral reactivation from latency. Although a variety of gene products are expressed from this region, the 72-kDa IE1 and the 86-kDa IE2 nuclear phosphoproteins are the most abundant and important. Both proteins have long been recognized as promiscuous transcriptional regulators. More recently, a critical role of the IE1 and IE2 proteins in counteracting non-adaptive host cell defense mechanisms has been revealed. In this review we will briefly summarize the available literature on IE1- and IE2-dependent mechanisms contributing to CMV evasion from intrinsic and innate immune responses.
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