Journal
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
Volume 66, Issue 3-4, Pages 191-198Publisher
WALTER DE GRUYTER GMBH
DOI: 10.5560/ZNC.2011.66c0191
Keywords
Single-Embryo; Embryogenesis; Metabolomics
Funding
- [20870024]
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Metabolites, the end products of gene expression in living organisms, are tightly correlated with an organism's development and growth. Thus, metabolic profiling is a potentially important tool for understanding the events that have occurred in cells, tissues, and individual organisms. Here, we present a method for predicting the developmental stage of zebrafish embryos using novel metabolomic non-target fingerprints of single-embryos. With this method, we observed the rate of development at different temperatures. Our results suggest that this method allows us to analyse the condition, or distinguish the genotype, of single-embryos before expression of their ultimate phenotype.
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