4.1 Article

Grating-based darkfield imaging of human breast tissue

Journal

ZEITSCHRIFT FUR MEDIZINISCHE PHYSIK
Volume 23, Issue 3, Pages 228-235

Publisher

ELSEVIER
DOI: 10.1016/j.zemedi.2013.01.001

Keywords

X-ray imaging; darkfield imaging; Talbot-Lau; mammography; breast cancer; microcalcification

Funding

  1. German Federal Ministry of Education and Research (BMBF) within the PHACT project

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Mastectomy specimens were investigated using a Talbot-Lau X-ray imaging set-up. Significant structures in the darkfield were observed, which revealed considerably higher contrast than those observed in digital mammography. Comparison with the histomorphometric image proofs that the darkfield signal correlates with a tumor region containing small calcification grains of 3 to 30 mu m size.

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