Journal
Zebrafish
Volume 5, Issue 4, Pages 237-242Publisher
MARY ANN LIEBERT INC
DOI: 10.1089/zeb.2008.0577
Keywords
-
Categories
Funding
- NIAMS [IRO1 AR 052535]
- Jake Gittlen Cancer Research Foundation
- Pennsylvania Tobacco Settlement Funds
Ask authors/readers for more resources
As genetic model systems, fish have played a key role in our understanding of a wide range of biological processes, including vertebrate pigmentation. In this review, we focus on one aspect of pigmentation, skin pigmentation, which has been of momentous importance in human history. Two fish models, medaka and zebrafish, played important roles in demystifying skin color and, by extension, the concept of race. Related thinking has the potential to make two additional contributions to human welfare. Fish can be used to validate gene candidates from genome-wide association studies (GWAS) in what has been called Systems Genetics. Because fish are familiar vertebrates, and share genetic mechanisms of skin color with humans, they also have outstanding potential as an educational tool-to demystify race, to increase public understanding of the role of model systems and evolution in science, and to enhance appreciation of both genetic and environmental factors that impact human health and society.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available