Journal
ZEBRAFISH
Volume 5, Issue 2, Pages 121-123Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/zeb.2008.9988
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Funding
- NIDA NIH HHS [R01 DA014546-05, R01 DA014546-02, R01 DA014546-03, R01 DA014546-06A1, R01 DA014546, R01 DA014546-07S1, R01 DA014546-07, R01 DA014546-08, R01 DA014546-04, R01 DA014546-01, DA14546] Funding Source: Medline
- NIGMS NIH HHS [R01 GM063904-06, R01 GM063904-07, R56 GM063904-08, GM63904, R01 GM063904, R01 GM063904-03, R56 GM063904, R01 GM063904-05, R01 GM063904-04, R01 GM063904-01, R01 GM063904-02, R01 GM063904-03S1] Funding Source: Medline
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The ability to manipulate the genome is critical to develop and test hypotheses based on genetics. Knockdown strategies focused on RNAi and/or morpholinos are excellent genetic tools, but they come with substantial technical limitations. A new gene targeting approach employing synthetic zinc finger nuclease (ZFN) technology is a powerful and complementary approach to directly modify genetic loci for many diverse applications, notably enhancing Danio rerio (the zebrafish) as an experimental organism for understanding human disease. This ZFN-based technology to generate targeted knockouts in this aquatic animal opens the door to an array of new biological models of human disease and genetic testing.
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