Journal
YONSEI MEDICAL JOURNAL
Volume 53, Issue 3, Pages 654-657Publisher
YONSEI UNIV COLL MEDICINE
DOI: 10.3349/ymj.2012.53.3.654
Keywords
Silver nanoparticles; macrophages; endocytosis; phagocytosis; IL-8
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Funding
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2011-0019160]
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Phagocytosis or endocytosis by macrophages is critical to the uptake of fine particles, including nanoparticles, in order to initiate toxic effects in cells. Here, our data enhance the understanding of the process of internalization of silver nanoparticles by macrophages. When macrophages were pre-treated with inhibitors to phagocytosis, caveolin-mediated endocytosis, or clathrin-mediated endocytosis, prior to exposure to silver nanoparticles, Interleukin-8 (IL-8) production was inhibited. Although cell death was not reduced, the inflammatory response by macrophages was compromised by phagocytosis and endocytosis inhibitors.
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