Journal
YEAST
Volume 27, Issue 9, Pages 727-739Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/yea.1769
Keywords
biofilm; Candida; farnesol; quorum sensing
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Diseases caused by Candida species are an increasing problem. Candida species are associated with high overall mortality, due to a variety of virulence factors such as the yeast-to-hyphal switch and proteolytic enzymes. The phenomenon of microbial communication known as quorum sensing also seems to play an important role. The main characteristics of the quorum-sensing molecule E, E-farnesol are well known for C. albicans. The present study focused on two questions. One of them concerned the secretion of E, E-farnesol by C. albicans and involved a close examination of the effect of the medium (serum) and the origin of the isolates used. The second one dealt with the activity of E, E-farnesol in non-C. albicans species, such as C. tropicalis and C. parapsilosis, e. g. its impact on biofilm formation and growth. Under serum conditions, C. albicans produced up to 58% more E, E-farnesol at 37 degrees C than at 30 degrees C. The growth of all isolates was reduced and delayed by the administration of E, E-farnesol. Of all Candida species, C. tropicalis isolates were most strongly affected by the addition of E, E-farnesol. Biofilm formation on polystyrene was affected by E,E-farnesol treatment in all non-C. albicans species and C. albicans. E, E-farnesol exerts its main effect by altering the metabolic activity and growth inhibition of treated Candida species. The results obtained indicate that the presence of E, E-farnesol in the environment not only regulates the morphology of the Candida species but also affects its fitness. In this regard, the secretion of E, E-farnesol might provide an advantage for members of the microbial community. Copyright (C) 2010 John Wiley & Sons, Ltd.
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