Journal
YEAST
Volume 26, Issue 4, Pages 205-220Publisher
WILEY
DOI: 10.1002/yea.1660
Keywords
Transcription; coactivators; ordered recruitment; chromatin remodeling; GAL; PHO; HO; Gcn4
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Activated transcription in eukaryotes requires the aid of numerous co-factors to overcome the physical barriers chromatin poses to activation, bridge the gap between activators and polymerase, and ensure appropriate regulation. S. cerevisiae has long been a model organism for studying the role of co-activators in the steps leading up to gene activation. Detailed studies on the recruitment of these co-activators have been carried out for more than a dozen promoters. Taking a step back to survey, these results, however, suggests that there are few generalizations that could be used to guide future studies of uncharacterized promoters. Copyright (C) 2009 John Wiley & Sons, Ltd.
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