Journal
JOURNAL OF CANCER
Volume 6, Issue 8, Pages 694-700Publisher
IVYSPRING INT PUBL
DOI: 10.7150/jca.11709
Keywords
apicobasal polarity; esophageal adenocarcinoma; esophageal squamous cell carcinoma; LKB1; LGL1; SCNN1
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Funding
- American Heart Association [14GRNT20130034]
- National High Technology Research and Development Program of China [2012AA02A201-1]
- Science and Technology Development Plan of China [112102310283, 122102310198]
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Esophageal cancer is an aggressive disease featured by early lymphatic and hematogenous dissemination, and is the sixth leading cause of cancer-related deaths worldwide. The proper formation of apicobasal polarity is essential for normal epithelium physiology and tissue homeostasis, while loss of polarity is a hallmark of cancer development including esophageal oncogenesis. In this review, we summarized the stages of esophageal cancer development associated with the loss or deregulation of epithelial cell apicobasal polarity. Loss of epithelial apicobasal polarity exerts an indispensable role in the initiation of esophageal oncogenesis, tumor progression, and the advancement of tumors from benign to malignant. In particular, we reviewed the involvement of several critical genes, including Lkb1, claudin-4, claudin-7, Par3, Lgl1, E-cadherin, and the Scnn1 gene family. Understanding the role of apicobasal regulators may lead to new paradigms for treatment of esophageal tumors, including improvement of prognostication, early diagnosis, and individually tailored therapeutic interventions in esophageal oncology.
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