Journal
XENOTRANSPLANTATION
Volume 17, Issue 4, Pages 267-273Publisher
WILEY
DOI: 10.1111/j.1399-3089.2010.00601.x
Keywords
CD47; macrophage; signaling regulatory protein alpha; tolerance; xenotransplantation
Categories
Funding
- NIH [RO1 AI064569, PO1 AI045897]
- JDRF [1-2005-72]
- ROTRF [848155553]
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Robust immune responses to xenografts remain a major obstacle to clinical translation of xenotransplantation, which could otherwise be a potential solution to the worldwide shortage of organ donors. The more vigorous xenograft rejection relative to allograft rejection is largely accounted for by the extensive genetic disparities between the donor and recipient. Xenografts activate host immunity not only by expressing immunogenic xenoantigens that provide the targets for immune recognition and rejection, but also by lacking ligands for the host immune inhibitory receptors. This review is focused on recent findings regarding the role of CD47, a ligand of an immune inhibitory receptor SIRP alpha, in xenograft rejection and induction of xenotolerance.
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