Journal
WORLD JOURNAL OF SURGICAL ONCOLOGY
Volume 12, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1477-7819-12-304
Keywords
Etiology; Meta-analysis; NSAIDs; Prostate cancer
Funding
- National Key Clinical Specialty Construction Project of China
- key medical disciplines of Zhejiang province
- Combination of traditional Chinese and Western medicine key disciplines of Zhejiang province [2012-XK-A23]
- health sector scientific research special project [201002010]
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Background: Epidemiological studies of the association between nonsteroidal anti-inflammatory drug (NSAID) intake and the risk of prostate cancer still remain controversial. Therefore, we conducted a meta-analysis to evaluate the potential association between NSAID intake and prostate cancer risk. Methods: Eligible studies were retrieved by both computerized searches and reviews of references. Subgroup analyses on country and design of study were also performed. Random or fixed-effect models were used to pool estimates of odds ratios (ORs) with 95% confidence intervals (CIs). Results: We observed that the intake of aspirin was associated with a marginally decreased risk of prostate cancer (OR =0.95, 95% CI =0.93 to 0.98). A similar result was found between nonaspirin NSAIDs and prostate cancer risk (OR =0.94, 95% CI =0.90 to 0.98). However, a positive relation between all-NSAID intake and prostate cancer risk was observed (OR =1.18, 95% CI =1.15 to 1.22). Conclusions: We observed a marginally inverse correlation between the intake of aspirin and prostate cancer risk. On the contrary, a positive relationship between all-NSAID intake and prostate cancer was detected. Further research needs to be conducted to better clarify potential biological mechanisms.
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