Journal
WORLD JOURNAL OF SURGERY
Volume 37, Issue 11, Pages 2688-2692Publisher
SPRINGER
DOI: 10.1007/s00268-013-2156-9
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Background The prognostic nutritional index (PNI), which is calculated based on the serum albumin concentration and peripheral blood lymphocyte count, is a useful tool for predicting short-term and long-term postoperative outcome in patients undergoing cancer surgery. However, few studies have investigated PNI in colorectal cancer surgery. We examined the ability of PNI to predict shortand long-term outcomes in patients with colorectal cancer. Methods This retrospective study included 365 patients who underwent resection for colorectal cancer. The prognostic nutritional status was calculated on the basis of admission data as follows: 10 x serum albumin (g/dl) + 0.005 x total lymphocyte count (per mm(3)). The primary outcomes measured were the impact of PNI on overall survival and postoperative complications. Results Kaplan-Meier analysis and the log rank test revealed that low PNI was significantly associated with poor survival (P < 0.0001). In multivariate analysis for survival, preoperative low PNI was an independent prognostic factor for poor survival: odds ratio: 2.25, 95 % confidence interval 1.42-3.59). Moreover, low PNI significantly correlated with the incidence of postoperative complications, especially serious ones. Conclusions Preoperative PNI is a useful predictor of postoperative complications and survival in patients with colorectal cancer.
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