Journal
WORLD JOURNAL OF SURGERY
Volume 35, Issue 5, Pages 1055-1062Publisher
SPRINGER
DOI: 10.1007/s00268-011-1000-3
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The aim of this study was to estimate the survival rates and define risk factors for tumor recurrence after resection surgery for single hepatocellular carcinomas (HCCs) <= 5 cm (on preoperative imaging) that developed on compensated cirrhosis. A retrospective review studied patients treated by surgical resection. Overall survival (OS), disease-free survival (DFS), recurrence rates, and risk factors were studied for all patients. A total of 49 patients were treated by resection. The 5-year OS and DFS rates were 52 and 41%, respectively, after 2000. Three independent risk factors were found for OS and DFS: macroscopic vascular invasion, satellite nodules, R1 resection. In the absence of these three factors, the 5-year OS was 59%. Recurrence rates were 63%. Delayed recurrence was significantly related to the 5-year OS. One factor was correlated with early recurrence: the presence of satellite nodules; and one factor was correlated with late recurrence: hepatitis C virus infection. R0 resection for HCC on compensated cirrhosis may offer good long-term survival in the absence of satellites nodules and macrovascular invasion. Thus, a first approach resection is proposed with the possibility of salvage transplantation. In other cases, resection may be a bridge to transplantation (transplantation de principe).
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