Journal
WORLD JOURNAL OF SURGERY
Volume 35, Issue 8, Pages 1725-1731Publisher
SPRINGER
DOI: 10.1007/s00268-010-0952-z
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Funding
- St. Luke's Episcopal Hospital, Houston, Texas [09RDM006, 09RDM007]
- Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas [09-10]
- NIH [R21CA140828, T32HL083774]
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Pancreatic cancer (PC) is an aggressive malignancy with poor survival. The discovery of microRNAs (miRNAs) has provided a new opportunity to study the disease. Thus far, altered expression of miRNAs has been reported in a wide range of malignancies, including PC, and some miRNAs are associated with PC cell proliferation, invasion, chemoresistance, and patient survival. This review summarizes recent advances with respect to the roles and mechanisms of miRNAs in PC and discusses potential clinical applications.
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