Journal
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
Volume 30, Issue 3, Pages 1019-1025Publisher
SPRINGER
DOI: 10.1007/s11274-013-1520-0
Keywords
Fermentation; Ginseng extracts; Ginsenoside; Ovarian cancer cells
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Funding
- Ministry of Education of China [20112201110001]
- National Natural Science Foundation of China [20862017]
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A total of 58 isolates of beta-glucosidase-producing microorganisms were isolated from soil around the wild ginseng roots under forest using Esculin-R2A agar. Among these isolates, strain GS33 showed a strong ability to convert ginsenosides Rb1, Rb2, Rc, and Rd into F2, Rg3, C-K, and convert ginsenoside Rg1 into Rh1, and F1. Fermented ginseng products can inhibit ES-2 cells growth and the IC50 value was 0.73 mg ml(-1). Phylogenetic analysis based on 16S rRNA gene sequences indicated that the strain GS33 belongs to the genus Penicillium and is most closely related to Penicillium simplicissimum (99 %).
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