Resveratrol lacks antifungal activity against Candida albicans

The putative candicidal activity of resveratrol is currently a matter of controversy. Here, the antifungal activity as well as the antioxidant response of resveratrol against , have been tested in a set of strains with a well-established genetic background At the doses usually employed in antifungal tests (10-40 mu g/ml), resveratrol has no effect on the exponential growth of the CAI.4 strain, a tenfold increase (400 mu g/ml) was required in order to record a certain degree of cell killing, which was negligible in comparison with the strong antifungal effect caused by the addition of amphotericin B (5 mu g/ml). An identical pattern was recorded in the prototrophic strains of SC5314 and RM-100, whereas the oxidative sensitive trehalose-deficient mutant ( strain) was totally refractory to the presence of resveratrol. In turn, the serum-induced yeast-to-hypha transition remained unaffected upon addition of different concentrations of resveratrol. Determination of endogenous trehalose and catalase activity, two antioxidant markers in ; revealed no significant changes in their basal contents induced by resveratrol. Collectively, our results seem to dismiss a main antifungal role as well as the therapeutic application of resveratrol against the infections caused by .