Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 64, Issue 15, Pages 785-791Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2015.1030648
Keywords
Biopolyesters; corneal keratocytes; electrospinning; polycaprolactone; polyhydroxybutyrate; polyhydroxybutyrate-co-hydroxyvalerate
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Funding
- University of Malaya [PV-107-2012A]
- Ministry of Education Malaysia [UM.C/HIR/MOHE/ENG/44]
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In vitro drug screening techniques provide rapid and easy to analyze data, while saving a lot of animals from being sacrificed. An important part of any in vitro drug screening platform is a biomaterial which promotes cell growth and proliferation. The potential of electrospun scaffolds made of polyhydroxybutyrate (PHB), poly (3-hydroxybutyric acid-co-3-hydroxyvaleric acid) (PHBV), and polycaprolactone (PCL) were studied to serve as drug screening platform for corneal keratocyte tissues. The results showed that the proliferation rate was slightly higher for PCL and PHBV on day 7. Gene expression results showed that PCL was the best in maintaining keratocyte genes. [GRAPHICS] .
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