Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 20, Issue 25, Pages 8092-8101Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v20.i25.8092
Keywords
Metabolomics; Gastric cancer; Chemosensitivity; Metastasis; Biomarkers; Nuclear magnetic resonance spectroscopy; Liquid/gas chromatography and mass spectrometry
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Funding
- Research Council of Norway [70174300]
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Metabolomics is a field of study in systems biology that involves the identification and quantification of metabolites present in a biological system. Analyzing metabolic differences between unperturbed and perturbed networks, such as cancerous and non-cancerous samples, can provide insight into underlying disease pathology, disease prognosis and diagnosis. Despite the large number of review articles concerning metabolomics and its application in cancer research, biomarker and drug discovery, these reviews do not focus on a specific type of cancer. Metabolomics may provide biomarkers useful for identification of early stage gastric cancer, potentially addressing an important clinical need. Here, we present a short review on metabolomics as a tool for biomarker discovery in human gastric cancer, with a primary focus on its use as a predictor of anticancer drug chemosensitivity, diagnosis, prognosis, and metastasis. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
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