Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 20, Issue 34, Pages 11929-11934Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v20.i34.11929
Keywords
Alcoholic liver disease; Alcoholic hepatitis; Hepatitis C virus infection; Corticosteroids; Transplantation
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Hepatitis C virus (HCV) infection and alcohol abuse are two most important causes of chronic liver disease in the United States. Alcoholic hepatitis is a unique clinical syndrome among patients with chronic and active alcohol abuse with a potential for high short-term mortality. About 20% of patients presenting with alcoholic hepatitis have concomitant HCV infection. Mortality from alcoholic hepatitis is increased in the presence of concomitant hepatitis C due to synergistic interaction between HCV and alcohol in causing hepatocellular damage. Large prospective randomized studies are needed to develop guidelines on the use of corticosteroids among patients with alcoholic hepatitis and concomitant HCV infection. The impact of antiviral therapy on mortality and outcome in the setting of alcoholic hepatitis remains a novel area for future research. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
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