Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 20, Issue 20, Pages 6279-6286Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v20.i20.6279
Keywords
Alcoholic hepatitis; Pathogenesis; Treatment; Model for end stage liver disease; Discriminant function; Lille Model; Glasgow alcoholic hepatitis score; Liver transplantation
Categories
Funding
- NIH/NIAAA [K08 AA016570]
- Veterans Affairs Research and Administration, Indiana University Research Support Fund [1I01-CX000361-01]
- United States Department of Defense [W81XWH-12-1-0497]
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Alcoholic hepatitis (AH) is an acute hepatic inflammation associated with significant morbidity and mortality. Current evidence suggests that the pathogenesis is the end result of the complex interplay between ethanol metabolism, inflammation and innate immunity. Several clinical scoring systems have been derived to predict the clinical outcomes of patients with AH; such as Child-Turcotte-Pugh score, the Maddrey discriminant function, the Lille Model, the model for end stage liver disease scores, and the Glasgow alcoholic hepatitis score. At present, Corticosteroids or pentoxifylline are the current pharmacologic treatment options; though the outcomes from the therapies are poor. Liver trans-plantation as the treatment of alcoholic hepatitis remains controversial, and in an era of organ shortage current guidelines do not recommend transplantation as the treatment option. Because of the limitations in the therapeutic options, it is no doubt that there is a critical need for the newer and more effective pharmacological agents to treat AH. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
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