Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 20, Issue 45, Pages 17029-17036Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v20.i45.17029
Keywords
Apple; Berry; Chemoprevention; Colon cancer; Fruit juices; Phytochemicals
Categories
Funding
- Ministry of Higher Education Malaysia
- Ministry of Education [04H93]
- [R.J130000.7809.4F444]
- [PY/2014/03167]
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Colon cancer arises due to the conversion of precancerous polyps (benign) found in the inner lining of the colon. Prevention is better than cure, and this is very true with respect to colon cancer. Various epidemiologic studies have linked colorectal cancer with food intake. Apple and berry juices are widely consumed among various ethnicities because of their nutritious values. In this review article, chemopreventive effects of these fruit juices against colon cancer are discussed. Studies dealing with bioavailability, in vitro and in vivo effects of apple and berry juices are emphasized in this article. A thorough literature survey indicated that various phenolic phytochemicals present in these fruit juices have the innate potential to inhibit colon cancer cell lines. This review proposes the need for more preclinical evidence for the effects of fruit juices against different colon cancer cells, and also strives to facilitate clinical studies using these juices in humans in large trials. The conclusion of the review is that these apple and berry juices will be possible candidates in the campaign against colon cancer. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
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