Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 19, Issue 8, Pages 1193-1199Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v19.i8.1193
Keywords
Portal hypertension; Hepatic venous pressure gradient; Clinically significant portal hypertension; Liver stiffness; Liver cancer; Hepatocellular carcinoma; Resection; Radiofrequency ablation; Percutaneous ethanol injection
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The incidence of hepatocellular carcinoma (HCC) is rising worldwide being currently the fifth most common cancer and third cause of cancer-related mortality. Early detection of HCC through surveillance programs have enabled the identification of small nodules with higher frequency, and nowadays account for 10%-15% of patients diagnosed in the West and almost 30% in Japan. Patients with small HCC can be candidates for potential curative treatments: liver transplantation, surgical resection and percutaneous ablation, depending on the presence of portal hypertension and co-morbidities. This review will analyze recent advancements in the clinical management of these individuals, focusing on issues related to the role of portal hypertension, the debate between resection and ablative therapies and the future impact of molecular technologies. (C) 2013 Baishideng. All rights reserved.
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