Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 19, Issue 45, Pages 8192-8202Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v19.i45.8192
Keywords
Helicobacter pylori; Interleukin-8; Signals; Gastric cancer; Therapeutics
Categories
Funding
- National Cancer Center [0720570]
- National Research Foundation of Korea (NRF)
- Basic Research Program [2010-0009910]
- MRC for Gene Regulation [2011-0030132]
- Korea government (MSIP)
- National Research Foundation of Korea [2010-0009910] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ask authors/readers for more resources
Helicobacter pylori (H. pylori) is a major etiological factor in the development of gastric cancer. Large-scale epidemiological studies have confirmed the strong association between H. pylori infection and both cancer development and progression. Interleukin-8 (IL-8) is overexpressed in gastric mucosa exposed to H. pylori. The expression of IL-8 directly correlates with a poor prognosis in gastric cancer. IL-8 is multifunctional. In addition to its potent chemotactic activity, it can induce proliferation and migration of cancer cells. In this review, we focus on recent insights into the mechanisms of IL-8 signaling associated with gastric cancer. The relationship between IL-8 and H. pylori is discussed. We also summarize the current therapeutics against IL-8 in gastric cancer. (C) 2013 Baishideng Publishing Group Co., Limited. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
