Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 19, Issue 40, Pages 6710-6713Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v19.i40.6710
Keywords
Clostridium difficile; Pseudomembranous enterocolitis; Proton pump inhibitors; Anti-bacterial agents; Pharmacoepidemiology; Public health; Disease outbreaks; Epidemics
Categories
Funding
- National Institute of Diabetes and Digestive and Kidney Diseases [T32 DK083256-0]
- National Cancer Institute Career Development Award [K07 CA 132892]
Ask authors/readers for more resources
Once a nosocomial disease, Clostridium difficile infection (CDI) now appears frequently in the community in the absence of exposure to antibiotics. Prior studies have shown that patients with community-acquired CDI are younger, more likely to be female, and have fewer comorbidities compared to patients with hospital-associated CDI. Because most studies of CDI are hospital-based, comparatively little is known about community-acquired CDI. The recent study by Chitnis has received widespread attention because it used active surveillance to capture all cases of community-acquired CDI within a large population and assessed key risk factors. The authors found that low-level healthcare exposure and proton pump inhibitor use were common among those with non-antibiotics associated, community-acquired CDI. In this commentary, we discuss the changing epidemiology of community-acquired CDI and the evidence basis for the controversial association between proton pump inhibitors and community-acquired CDI. (C) 2013 Baishideng. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available